Great talk by Dr. Dalip Sethi (Senior Scientist - Terumo BCT) @ the opening of the CAR-TCR Europe 2020 conference highlighting the many challenges associated with bringing CAR-T's from bench to bedside, both from a process and standardisation perspective.

CAR-T therapies offer the potential to revolutionise cancer treatment; however, there are many challenges associated with effectively incorporating this treatment into the healthcare system from a process perspective - some of which are highlighted below:

  1. METHODS: The methods used to produce CAR-T's need to be controlled, reproducible and standardised
  2. PROCESSES: Processes need to be flexible to effectively incorporate CAR-T's into the healthcare system
  3. STARTING MATERIALS: There is a great degree of variability in the starting materials used to generate CAR-T's and this may effect efficacy and long-term outcomes
  4. VARIABILITY: There is a great degree of variability in the apheresis protocols used to generate CAR-T's and this may effect CAR-T titres