There are growing concerns that much of the published research may be false... 

What started as a provocative and thoughtful publication back in 2005 has led to what is now being described as a "reproducibility crisis" and an "epidemic of statistical significance" that calls in to question the foundations of science and evidence-based medicine.  

The following article from @B_Resnick provides a detailed exploration of the core issues, and gives an insight into a debate which could one day impact everyone working in scientific communication.